Journal of Clinical & Experimental Dermatology Research
Open Access

Hemidesmosome proteins in the skin: Structure, disorders and control

16^th European Dermatology Congress

June 07-08, 2017 Milan, Italy

Alireza Nasoori

Hokkaido University, Japan

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Autoimmune skin disorders cause challenging clinical issues that have yet to be studied. Hemidesmosomes (HDs) are the crucial structural proteins in the skin (Fig. 1). When HDs are compromised by immune system, severe skin lesions such as epidermolysis bullosa simplex and bullous pemphigoid can occur. These lesions are usually controlled by immunosuppressive and anti-inflammatory treatments. However, the blisters which remain by the disease should be protected against infection and biofilms. Traditional medicine may open up ways for such cases. In this respect, maggot therapy (the use of larvae of Lucilia sericata) has provided satisfactory outcomes for wound treatment due to debridement of the biofilm, and improvement of regeneration. The extract (secretion and excretion) of the maggots has antimicrobial, anti-inflammatory and tissue regenerative properties. Thus, invivo and in-vitro investigations of the efficacy of maggots��? extract for management of autoimmune blistering disorders are worth consideration.

Biography :

Email: alinasoori@eis.hokudai.ac.jp