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Seyed Mohammad Radmanesh
Ahvaz Jundishapur University of Medical Sciences, Iran
Scientific Tracks Abstracts: J Clin Exp Dermatol Res
Monobenzyl ether of hydroquinone is a melanocytotoxic drug which is used for depigmentation of normally pigmented patches in extensive and generalized vitiligo. Cases have been reported that following application of MBEH depigmention has developed in remote areas not directly in contact with MBEH. The term chemical vitiligo has been applied to this situation. I visited four patients who developed generalized vitiligo after using MBEH for the treatment of intractable melasma. The lesions were started first as mottled depigmented patches on the face, where the MBEH was applied for a long time followed by development of vitiligo patches on the fingers, dorsum of the hands and forearm and then extended to other areas. The MBEH was reported to induce some immunological changes through which it may exert its melanocytotoxic activities. These melanocytotoxic activities may be used as an alternative therapy for melanomas. This finding supports the theory that not all vitiligos are inherited immune-genetic in nature, some may develop as a result of exposure to toxic chemicals such as MBEH or other unknown chemicals. These melanocytotoxic chemicals may exert their effects through changing the immunological profile of the tissue and subsequent death of melanocytes and vitiligo development.
Seyed Mohammad Radmanesh has completed his Medicine and Dermatologic Residency in Shiraz University of Medical Sciences previously known as Pahlavi University and received the National Board of Dermatology in 1993. From 1993, he is an Academic Member of Ahvaz University of Medical Sciences, Iran. He is currently an Associate Professor of Dermatology. One of the fields of his interest is vitiligo. He has published several papers in the literature, some are the reference papers.