Fibrous cephalic plaques in tuberous sclerosis complex | 9497
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 7868 792050

Fibrous cephalic plaques in tuberous sclerosis complex

14th International Conference on Clinical and Experimental Dermatology

June 19-20, 2017 Philadelphia, USA

Oyetewa Oyerinde, Danielle Buccine, Joel Moss and Thomas N Darling

National Institutes of Health, USA
Uniformed Services University of the Health Sciences, USA

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Fibrous cephalic plaques (FCPs) prototypically develop on the forehead of patients with tuberous sclerosis complex (TSC). They constitute a major feature for the diagnosis of TSC, and may be present before other TSC-related cutaneous hamartomas. We aimed to describe the clinical characteristics of FCPs in TSC. 115 adult patients with TSC were enrolled in an observational cohort study. A retrospective analysis of medical records and skin photography was performed. FCPs were categorized per anatomic location and size. Overall, 36% (41/115) of patients had at least one FCP on the scalp, face, or neck. 61 total lesions from the 41 patients were classified according to size; 57% 1 to <5 cm, 13% â�?¥5 cm, and 26% unknown due to prior excision. The distribution of lesions was 35% scalp, 37% forehead, 23% face (non-forehead) and 5% neck. The lesions showed a left-sided predilection; 61% left sided versus 28% right sided and 10% midline. Of the 11 lesions that were histopathologically analyzed, most were characterized by dermal collagenosis with marked decrease of dermal elastic fibers. Only about one-third of FCPs was present on the classic location of the forehead, with the remainder split between other locations on the face or scalp. Better recognition of these lesions by clinicians may lead to earlier diagnosis of TSC.

Biography :