Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Irshad Hussain and Abdul Manan Bhutto
SMBB Medical University, Pakistan
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Vitiligo vulgaris is an ailment that has profound impact on pigmentation of the human skin. Different therapeutic regimens are used to treat vitiligo but none of them alone is too successful to be called as vitiligo cure. Recently, a change has been observed with the development of anti-vitiligo ointment containing hydroalchoholic extract (distilled water and methanol in 1:1 ratio) of ground seed of Psoralia corylifolia (P.C). The study aimed to explore the clinical outcome of ointment formulation containing hydroalchoholic extract of Psoralia corylifolia. 20 patients (aged 25-65 years) were included in this study. Formulation was applied on effected white patches of patients and some effected portion of the same patient was regarded as control (self control study design). The formulation that passed the required tests (pH, the temperature stability tests in 8�?±0.1 �?°C, 25�?±0.1 �?°C, 40�?±0.1 �?°C and the physical properties like color, bleeding and rheology) was selected. FTIR studies of hydroalchoholic extract of P.C seeds and formulation were performed. The pigmentation of white spots of vitiligo was photographically evaluated before, during and after 12 weeks of treatment. A significant (pâ�?¤ 0.05) reduction in the pigmentation of skin was determined in the volunteers used herbal extract. Pre and post treatment difference in the levels of pigmentation was statistically significant (p=0.05). Hydrophilic ointment prepared from herbal extract was found effective in vitiligo as compared to self control. Ointment formulation containing hydroalchoholic extract of P.C could be an effective monotherapy for vitiligo.
Email: irshadpharmacist@yahoo.com