Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Barkat Ali Khan and Irshad Hussain
Gomal University D.I Khan, Pakistan
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Aims & Background: Vitiligo is a common disorder of human skin pigmentation leading to devastation and disfiguring the normal color of skin. Although multifactors have been suggested in etiology and different management options but still the medical science is in the search for definitive cause and ultimate cure of vitiligo. Plants have been reported to possess the anti-vitiligo spectrum particularly Psoralia corylifolia (PC) but there is a scientific exploration of this plant. This study was designed to formulate skin friendly emulsion (cream) from containing PC extract. Materials & Methods: Hydroalchohlic extract of grinded seed of PC was screened for the presence of phytochemistry. Antioxidant potential was measured by various radical scavenging assays (DPPH, nitric oxide, superoxide and hydroxyl). Total phenolic contents were calculated spectrophotometrically. Thirteen formulations (F1-F13) were attempted by variable concentration of emulsifying agent in accordance with response surface methodology (RSM). Three of the formulations containing 5% extract of PC were tested for stability at different temperature and humidity to optimize in vitro, the most suitable formulation. Rheology studies were performed to determine the viscosity and shear rate. Results: It was found that hydro alcoholic extracts of PC contained tannins, flavonoids, saponins, triterpenoids, steroids, glycosides and anthraquinones. Hydroalchoholic extract of PC possess significant radical scavenging potential (77.27%, 77.72%, 82.50 and 89.84% with increasing concentrations) and phenolic contents. An emulsion formulation containing 5% hydroalchohlic extract of PC was found stable at 0 oC, 8 oC, 25 oC and 30 oC. Conclusion: An emulsion containing 5% hydroalchoholic extract of PC can be used to explore bioactive natural products that may serve as leads in the development of new pharmaceuticals for vitiligo. The in vivo study of this finding will support the traditional use of PC for vitiligo.
Email: barki.gold@gmail.com