Journal of Hematology & Thromboembolic Diseases
Open Access

Extension of 2016 World Health Organization (WHO) classification into a new set of clinical, laboratory, molecular, and pathological criteria for the diagnosis of myeloproliferative neoplasms: from dameshek to vainchenke

9^th International Conference on Leukemia and Hematologic Oncology

October 05-06, 2017 London, UK

Jan Jacques Michiels

Goodheart Institute ,Netherlands

Scientific Tracks Abstracts: J Hematol Thrombo Dis

Abstract :

Improved Clinical, Laboratory, Molecular, and Pathological (CLMP) 2017 criteria for myeloproliferative neoplasms (MPN) define the JAK2V617F trilinear MPNs as a broad continuum of essential thrombocythaemia (ET), polycythaemia vera (PV), masked PV, and post-ET or post-PV myelofibrosis (MF). Normal versus increased erythrocyte counts (5.8 x 1012/L) on top of bone marrow histology separate JAK2V617F ET and prodromal PV from early and classical PV. Bone marrow histology of the JAK2V617F trilinear MPNs show variable degrees of normocellular megakaryocytic, erythrocytic megakaryocytic and erythrocytic megakaryocytic granulocytic (EMG) myeloproliferation, peripheral cytoses, and splenomegaly related to JAK2 V617F allele burden. MPL515 thrombocythaemia displays predominantly normocellular megakaryocytic proliferation. CALR (Calreticulin) thrombocythaemia initially presents with megakaryocytic followed by dual granulocytic and megakaryocytic myeloproliferation without features of PV. The megakaryocytes are large, mature, and pleomorphic with hyperlobulated nuclei in JAK2V617F ET and prodromal, classical, and masked PV. The megakaryocytes are large to giant with hyperlobulated staghornlike nuclei in MPL515 thrombocythaemia. The megakaryocytes are densely clustered, large, and immature dysmorphic with bulky (bulbous) hyperchromatic nuclei in CALR thrombocythaemia and MF.

Biography :

Jan Jacques Michiels is is the Professor of Nature Medicine and Health, Clinical and Molecular Genetics, Blood and Coagulation Research at the University Hospitals Antwerp, Brussels. He is the Editor of Journal of Hematology & Thromboembolic Diseases, World Journal of Hematology and Editor in Chief of World Journal of Clinical Cases.