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Mostafa Ibrahim Attia Abd Ellatif, Noha A Nagui, Laila A Rashed and Walaa M A Abd Elhafez
Cairo University, Egypt
Posters & Accepted Abstracts: Clin Exp Dermatol Res
Background: CTCL are non-Hodgkin lymphomas characterized by a dominant skin homing T-cell clone with different clinical presentations. MF is the most common subtype. It includes hypopigmented, hyperpigmented, ichthyosiform, pityriasis lichenoides like granulomatous, folliculotropic, bullous, palmo-plantar, pagetoid reticulosis and granulomatous slack skin, several gaps are still present in our understanding of the pathogenesis. The miRNAs are small non-coding RNA molecules involved in the regulation of various physiological and pathological processes. Altered expression of different miRNAs has been observed in both solid tumors and hematological malignancies. The miRNA-93, one of members of miR-17-92 cluster, which role was proved in enhanced cell survival, promoted sphere formation and augmented tumor growth. Objectives: The aim of this study is to evaluate the expression level of miRNA-93 in early stage MF. Methods: 15 patients with early stages MF as well as 15 age and sex matched healthy controls were included. Clinical examination was done and levels of miRNA-93 in both lesional and non lesional biopsies were assessed by PCR. Results: Significant increase in miRNA-93 in both lesional and non lesional biopsies of the patients in comparison to controls with more increase in its level in lesional skin than non lesional skin. There was significant positive correlation between miRNA-93 levels and age in both lesional and non lesional biopsies. Also there was significant positive correlation between miRNA-93 and duration in non lesional skin biopsies only. But there was no significant difference in miRNA-93 levels as regards sex of the patients, extent of disease or MF types in both lesional and non-lesional skin biopsies. Conclusion: Our study concluded that miRNA-93 may be used as a diagnostic tool of MF. Further studies are required to verify the role miRNA-93.