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Ilnaz Rashidi, Masood Sahraie Rad, Ali Karimi Bakhshandi and Tahereh Rezazadeh
Islamic Azad University, Iran
Pars AzmayeTeb Co., Iran
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Psoriasis is an autoimmune disease that is associated with itching and inflammation. In this disease, macrophages and dendritic cells make T-cells activated and differentiate them into T-helper 1 and T helper 7. Then, a number of cytokines release from these cells. For example, the expression levels of IFN├?┬│ decreased and it leads to irregular proliferation of keratinocytes or the reduction of TNF├?┬▒ resulted in inflammation. Also, the expression levels of IL4 and IL5 increased. Finally, it can also cause inflamed and thick in the skin. In this disease, itching, inflammation and severe dryness occur due to increase cell layers. Allantoin was used in the Cerita anti-psoriasis shampoo in order to create more hydration and decrease inflammation. The precursor of allantoin is uric acid. Therefore, 5 percent of uric acid was used in shampoo combination. As a result, allantoin helps to improve wound and inflammation by decreasing the expression of IL 4 and IL5. In this study, in specified areas of the scalp in 24 patients the red pigment was measured by colorimeter. Then, patients were asked to use Cerita anti-psoriasis shampoo every other day for 2 months. After, were measured from the representative area of the scalp and compared for the color difference. The results confirmed that allantoin decreases the inflammation.
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