Evaluation of synergistic effect of red clover extract with Bimat | 7732
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 7868 792050

Evaluation of synergistic effect of red clover extract with Bimatoprost in the treatment of eyelash discoloration in patients with vitiligo

Vitiligo and Skincare Physicians Meeting

September 15-16, 2016 Berlin, Germany

Ilnaz Rashidi, Masood Sahraie Rad, Ali Karimi Bakhshandi and Tahereh Rezazadeh

Islamic Azad University, Iran
Pars Azmaye Teb Co., Iran

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Vitiligo is an autoimmune disease in which the body makes antibody against its own melanocytes and the skin loses its pigment and color in patches. Also, the amount of hydrogen peroxide (H2O2) is very high compared to the normal individual range. Increased tumor necrosis factor alpha (TNF alpha) and interleukin-1 levels directly cause apoptosis and activate cell death pathway in eyelash follicle melanocytes. As a result, eyelashes turn white. Treatment methods such as psoralen and ultraviolet A irradiation (PUVA) or the use of steroids are effective in treating skin discoloration. But these methods are not usually effective in the case of eyelashes. When bimatoprost is used in Cerita eyelash enhancer solution, it increases melanin synthesis via induction of tyrosinase activity. Therefore, result indicated that bimatoprost increased the melanogenesis process. Also, red clover extracts is used in this solution. Red clover is a rich source of isoflavones and A, C, E vitamins (The maximum scale was used in the solution combination). Consequently, these compounds effectively reduce catalase activity and the amount of H2O2. Moreover, bimatoprost and red clover have a synergistic effect on each other. This study was performed on 50 infected patients. 25 people used Cerita eyelash enhancer solution and 25 people used a concurrent placebo control daily for a month. The result of observation in the scanning electron microscope confirmed that the color of eyelashes changed and gets darkened eyelashes in the first group 60% compared with the control group.

Biography :