Evaluation of protective efficacy of Secoisolariciresinol digluco | 51104
Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Evaluation of protective efficacy of Secoisolariciresinol diglucoside: A potential immunomodulatory phytoestrogen

2nd International Conference on Clinical & Cellular Immunology

October 15-17, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

J. Rajesha and Sadiq S. Moree

Scientific Tracks Abstracts: J Clin Cell Immunol

Abstract :

Objective: The present study was carried out to probe the anti-inflammatory potential of SDG in immunomodulating and antinflammatory effect and the immune system?s response to an inflammatory substance. Material: Adult male Wistar rats weighing 120-170 g were used throughout the study. Treatment: The animals were orally treated with 20, 40 and 80 mg/kg b.w of SDG. Methods: The thickness of the rat paw was measured using plethysmometer at 0-24 h. The tissue extracts and serums of animals were used for the analysis of NO, PGE2 and NGF using specific kits. One-way ANOVA followed by Student?s t-test were used to test the significance levels. Results: SDG at 80 mg/kg b.w. for one day period before the carrageenan injections significantly reduced (p<0.05) paw swelling (45.18%) and associated with decrease in NO levels in paw tissue and serum by 72.4 and 53.6%. other parameters like level of PGE2 was diminished by 39.21 and 32.56% and NGF levels by 43.1 and 46.1% respectively when compared with the control. Significance: SDG may be useful to improve localized and systemic inflammatory responses in a variety of human conditions and might provide useful phytomedical treatment against a variety of immunomodulatory effects and inflammatory disorders.