Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Jaspreet Kaur, Rupinder K Sodhi and Upendra K Jain
University of West Kordofan, Sudant
Posters-Accepted Abstracts: Med Aromat Plants
The present study was designed to investigate the potential of Coleus forskohlii plant extract- ��?forskolin��? in experimental dementia in Wistar rats. Dementia was induced by the administration of High Fat Diet (HFD) for 90 days. The effects on learning and memory were assessed using Morris Water Maze (MWM) test. A battery of biochemical tests such as brain Thiobarbituric Acid Reactive Species (TBARS), reduced Glutathione (GSH), Superoxide Dismutase (SOD), brain Acetylcholinesterase (AChE) activity, Myeloperoxidase (MPO) activity and total serum cholesterol levels were measured. Administration of high fat diet significantly impaired the learning and memory and also deleteriously affected the biochemical parameters. Administration of forskolin (20 mg/kg, p.o.) for 14 days significantly attenuated high fat diet induced memory deficits and the biochemical alterations. Combined administration of forskolin and Pregnane X Receptor (PXR) antagonist, ketoconazole (25 mg/kg, p.o.) significantly reduced the beneficial effects of forskolin in HFD treated rats. This study demonstrates that improvement of memory by forskolin administration may occur as an outcome of its antioxidative, anticholinergic, anti-inflammatory, hypolipidemic and amyloid lowering potential. The study also proposes the possible involvement of pregnane X receptors in the pathophysiology of experimental dementia.
Email: kaurjaspreet067@gmail.com