Hisham Al-Matubsi, Farqad B Hamdan and Maysoun A Al-Kaabi
University of Petra, Jordan
Nahrain University, Iraq
Um Al-Baneen Center for Infertility Treatment and IVF, Iraq
Posters & Accepted Abstracts: J Women's Health Care
To evaluate plasma Kisspeptin-10 (KP-10) and assess its relation to altered reproductive hormones in preeclamptic pregnant women. First time pregnant women n=100 at 20 weeks of gestation participated in this study and divided into pre eclamptics n=60 and normotensives n=40. KP-10, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), beta-Human Chorionic Gonadotropin (β-HCG), Estradiol (E2) and Progesterone (PRG) were evaluated during second and third trimesters of pregnancy for all women. Kisspeptin-10 levels were reduced in PE women compared with normotensive pregnancies. In 2nd trimester, area under Receiver-Operator Characteristic (ROC) curve was 0.662, positive and negative predictive values were 32.8 and 94.6 and test sensitivity and specificity were 55% and 87.5%, respectively. In the 3rd trimester, area under ROC curve was 0.747 positive and negative predictive values were 22.2 and 97.3 and test sensitivity and specificity were 83.3% and 67.5%, respectively. In PE patients, plasma KP-10 demonstrated inverse correlation with E2 (during the 2nd trimester), LH and FSH (during the 3rd trimester) and positively correlated with β-HCG (during the 3rd trimester). Relatively high KP-10 sensitivity with the largest area under the ROC curves during 2nd and 3rd trimester of pregnancy, suggesting that is statistically acceptable as a diagnostic screening tool to rule out the PE especially in 3rd trimester.
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