Liena de Regla Ponce Rey, Gloria del Barrio, Annele Roque and Sonia Resik
University of Havana, Cuba
Tropical Medicine Institute “Pedro Kouri”, Cuba
Posters & Accepted Abstracts: J Antivir Antiretrovir
Nature is a prominent source of broad amount of compounds derived seaweeds and plants with vary antimicrobial and antiviral activities. Seaweeds exhibit a number of medicinal properties, playing a fundamental role by curing many diseases. Their medicinal use by population makes them an interesting target to be evaluated as antivirals, taking into account the variety of chemical metabolites they own. It has been documented that Sargassum genera are an interesting target for treating many viral diseases cause by herpesvirus. However, the antiviral activity of Sargassum fluitans against these viruses is not very well documented in bibliography. The aim of this work was to evaluate the antiviral activity of extracts from Sargassum fluitans, against enteroviruses like poliovirus 1, coxsackievirus B5 and A24 and echovirus 9. The calculation of antiviral activity (EC50) was evaluated by means of cytopathic effect inhibition in Vero cells and with viral load using quantitative RT-PCR. Preliminarily, assays with hydroethanolic extracts showed that Sargassum species were non-cytotoxic at the evaluated concentrations and showed an inhibitory activity by diminishing the viral titer more than three log in relation to the virus control. The preliminary characterization of the extracts showed several active compounds such as sulfated polysaccharides.
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