Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
+44 1478 350008
ISSN: 2161-0398
+44 1478 350008
Ik-Soo Shin
Soongsil University, South Korea
Scientific Tracks Abstracts: J Phys Chem Biophys
Recently, the use of electro-chemiluminescence (ECL) has drawn great attention due to its advantages such as high sensitivity, wide linear response range, good reproducibility and easy operation. However, ECL sensing of small molecules is still a great challenge because most of ECL detection methods have been developed via specific bio-macromolecular recognition such as antibody-antigen and aptamer-protein interactions. In the talk, the author will introduce about one of recent researches, the ECL chemodosimeter for the rapid determination of cyanide. A organometallic iridium(III) complex (1) with phenyl isoquinoline main ligands is rationally designed and synthesized for the ECL â??turn-onâ? molecular probe, and the dicyanovinyl branch attached to the end of the main ligand plays as a role of recognition site for cyanide. Upon the reaction with cyanide in aqueous solution, 1 displays drastically enhanced ECL emission with widely linear correlation between 0-0.40 mM of cyanide when the concentration of 1 is fixed to 10 uM. The method can be successfully applied in direct determination of cyanide in tab water, and the result shows that it is versatile enough for the rapid point-of-care determination of cyanide in the presence of interferences even with high reliability and reproducibility. Theoretical studies were carried out for the rational design of the probe by predicting its HOMO/LUMO energy levels as well as electronic distributions. This ECL-based chemodosimetric sensor suggests a new and versatile analysis platform for rapid determination of molecular toxins in real samples.
Ik-Soo Shin obtained his PhD degree from Seoul National University (SNU) in 2007. He was a Post-doctoral Fellow at the University of Texas in Austin and SNU. Currently, he is an Assistant Professor at Soongsil University in Korea. His research interests include the design and development of biosensors based on electrochemical method.
Email: extant@ssu.ac.kr