Chan Young Park, Eunyong Choi, Su-Man Yang, Kun Hee Park, Hye Jin Sim, Jung Hyun Choi, Ki-Moon Park, Hee-Jin Yang, Sung Hyun Ho, Su-JinPark and Seon-Hee Kim
Sungkyun Biotech Co. Ltd., Republic of Korea
Sungkyunkwan University, Republic of Korea
G&P Bioscience Co. Ltd., Republic of Korea
Posters & Accepted Abstracts: Medicinal & Aromatic Plants
Gaeddongssuk, Artemisia annua L. is an annual herb belonging to Asteraceae family which is grown popularly in Asia including Korean and China. The herb is well known for the effects of fever, hemostasis and antibiotics. When the mouse macrophage cell line, RAW264.7 was stimulated with LPS (Lipopolysaccharide) the cells tremendously secreted proinflammatory cytokines such as IL-1β (interleukin-1 beta), IL-6, NO (nitric oxide) and TNF α (Tumor Necrosis Factor alpha). However, the secretion of these cytokines was reduced from the cells treated with the extract of Artemisia annua L. (EAA). In addition, EAA was able to inhibit inflammatory reaction in the Acetaminophen (APAP)-stimulated human hepatocyte carcinoma cell line, HepG2 and to protect hepatocytes from damage caused by various toxins. Acute liver failure animal model was set up with injection of certain concentrations of LPS and D-galN (D-galactosamine) in C57BL/6J mice intraperitoneally, showing highly increased level of AST (Aspartate Transaminase) and ALT (Alanine Transaminase). Oral administration of EAA (100 mg/Kg) for 2 weeks reduced the level of AST and ALT up to 50% level of the negative control group treated with water vehicle. The efficacy of EAA was even more effective than one of the comparative positive control group treated with the extract of milk thistle. Moreover, EAA protected hepatic cells and tissues from oxidative stresses and inflammatory damages. Taken together, Artemisia annua L. demonstrated the possibilities as a promising nutraceutical candidate for protection and recovery of liver damages as well as maintaining liver health.