Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
ISSN: 2161-0398
Canice Chukwudi Anyachukwu, Onyeso, KK Ogochukwu
Posters-Accepted Abstracts: J Phys Chem Biophys
Acne Vulgaris, a common inflammatory disorder of the sebaceous gland presenting with comedones, papules, pustules, cysts and scares on the face, back, chest; with potential significant psychosocial morbidity. The efficacy of laser as an adjunct to self-management topical approach among males was studied. MATERIALS AND METHODS: 40 patients of University of Nigeria Enugu Campus within 16years-above diagnosed of facial acne were parallel randomized into laser group (n = 15) and placebo controlled single-blinded group (n= 20). Quota sampling was applied across the faculties to select and randomize subjects into laser and control groups as well as blocked randomization and balloting without replacement at allocation ratio of 1:1; for assignment of patient into laser and control group. Both patients and assessing physician were blinded. Treatment group had 905nm non-ablative infrared pulsed laser dose twice for 8 sessions while the control got a placebo through the 25cm2 quadrant and Global Acne Grading System- GAGS outcome measured. RESULTS: A significant improvement in clearance rate of acne occurred when laser was used as an adjunct therapy relative to control group (54.98% vs. 17.97%, t =9.773, p = <0.0001, C.I = 95%). Specifically, antibiotic cream (57.41% vs. 30.65%, p = 0.007), medicated soaps (50.00% vs. 25.00%, p = 0.013), talcum powder (57.43% vs. 10.34%, p = 0.005) and normal hygiene (53.57% vs. 5.90%, p = 0.006). CONCLUSIONS: A significant improvement in clearance rate of acne occurred when laser (adjunct) therapy was used to self-administered topical agents compared to the topical approach application alone.