Journal of Fundamentals of Renewable Energy and Applications
Open Access
ISSN: 2090-4541
+44 1300 500008
ISSN: 2090-4541
+44 1300 500008
Si Young Ha, Ji Young Jung and Jae-Kyung Yang
Gyeongsang National University, South Korea
Posters & Accepted Abstracts: J Fundam Renewable Energy Appl
More recently, Cordyceps militaris has been widely used due to its folkloric activities, which are not based on
scientific studies. Cordycepin (3�?�-deoxyadenosine), a metabolite of C. militaris, has been showed to inhibit the
growth of various tumor cells. Previous work reported the isolation of cordycepin from liquid culture medium of C.
militaris and its pharmacological functions. But, as far as we know, there is limited knowledge about the light emitting
diode (LED) condition for cordycepin production by C. militaris. In this paper, the effects of LED were focused in
order to improve the cordycepin production by submerged cultivation of C. militaris. For this experiment, mycelial
cultivation was performed in a shaking incubator at 24°C, 100 RPM for 5 days and the medium was sabouraud
dextrose broth (pH 5.6). The red, green and blue were used for the LED and dark culture and fluorescent lamp were
used as the control. This results, C. militaris showed the highest mycelial weight when green light was irradiated on the
other hand, when irradiated with blue light, the content of cordycepin is about 4 times higher than that of fluorescent
lamp in the cultures of C. militaris. In addition, the highest content of cordycepin was observed when irradiated for
6 h/day for 3 days. Interestingly, mycelial weight and cordycepin content were inversely related. The information
obtained is considered fundamental and useful to the development of C. militaris cultivation process for efficient
production of cordycepin on a large scale.
Recent Publications
1. Yang T, Guo M, Yang H, Gue S and Dong C (2016) The blue-light receptor CnWC-1 mediates fruit body
development and secondary metabolism in Cordyceps militaris. Applied microbiology and biotechnology
100:743-755.
2. Tuli H S, Sharma A K, Sandhu S S and Kashyap D (2013) Cordycepin: A bioactive metabolite with therapeutic
potential. Life sciences 93:863-869.
3. Kang C, Wen T C, Kang J C, Meng Z B, Li G R and Hyde K D (2014) Optimization of large-scale culture
conditions for the production of cordycepin with Cordyceps militaris by liquid static culture. The scientific world
journal 510627:1-15.
4. Huang L, Li Q, Chen Y, Wang X and Zhou X (2009) Determination and analysis of cordycepin and adenosine in
the products of Cordyceps spp. African Journal of Microbiology Research 3(12):957-961.
5. Shih I L, Tsai K and Hsieh C (2007) Effect of culture conditions on the mycelial growth and bioactive metabolite
production in submerged culture of Cordyceps militaris. Biochemical Engineering Journal 33:193-201.
Si Young Ha is student and PhD candidate of Gyeongsang National University in South Korea. She had retained a keen interest in applied and various fields of biomass. In particular, she has been studying the chemistry of woody biomass and their efficacy in treatment of vitiligo or atopic for a long time. She also has experience in poster presentation in the symposium on biotechnology for fuels and chemicals (2016) and bioenergy conference (2017).
E-mail: hellohsy2@gmail.com