Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Aina S. olawale
Lagos state university, Nigeria
Scientific Tracks Abstracts: Reprod Syst Sex Disord
Statement of the Problem: Infertility is a common socioeconomic problem, which study quoted that it has 9 to 18% prevalence in the general population. Clomiphene citrate (CC) is used in the management of infertile female.CC is a SERM, that increase GnRH with a rise in circulating LH and FSH. Estrus Cycle (EC) indices are good parameters for evaluating reproductive changes. While EC length determine what happens in the ovarian parenchyma, ECR predict relationship between follicular phase and the luteal phase of the menstrual cycle. High ECR means longer follicular phase, while its reduction means a prolonged luteal phase. Actual ova shed represent evidence of ovulation. The purpose of this study is to investigate how different doses of CC can affect the Estrus Cycle (EC), Estrus Cycle Ratio, (ECR) and ova shed (OS) in adult female rats. Methodology & Theoretical Orientation: Twenty-five (25) female Sprague Dawley (SD) rats were divided into 5 groups. Group A was the control while groups B, C, D, E were the treated groups. Group A received 0.5 ml of sterile water at diestrus. Groups B, C, D were given 0.2 mg/kg, 2 mg/kg, 4 mg/kg respectively at diestrus. Group E was given 6mg/kg/day of CC dissolved in sterile water. Administration, orally. Vaginal smear determines the various estrus phases and ECR was calculated, ova shed at estrus phase was evaluated at autopsy. Findings: There was a significant decrease (p<0.05) in estrus phases, ECR and ova shed in all treated groups compared with control. This study further shows that all the animal, groups (A-E) released ova. Conclusion & Significance: CC decreases EC length, reduces ECR and decreases the number of eggs released. CC contribute to fertility by increasing the luteal phase (egg availability), despite a decrease in number of egg release.
Aina olawale samson has expertise in reproductive health with several years of Obstetrics and Gynecological training. He also lectures physiology in a reputable university. He has shown great interest in integrating research outcomes into direct benefit in the clinical medicine. This has greatly made him show interest in the development of animal models of several human diseases and how these diseases can be managed. He has built a deep knowledge in research, clinical governance and teaching. He is willing to collaborate with researcher all over the world to improve the knowledge of science in the direction of animal modeling and clinical implications.