ISSN: 2155-9899
Derese Hailu, Awoke Derbie, Daniel Mekonin, Wondmagegn Mulu, Yesuf Adem, Alem Tsega and Fantahun Biadglegne
Bahir Dar Regional Health Research Laboratory Center, Ethiopia
Bahir Dar University, Ethiopia
Posters & Accepted Abstracts: J Clin Cell Immunol
Introduction & Aim: Pseudomonas aeruginosa has emerged as the most common gram-negative pathogen associated with serious
hospital-acquired infections, particularly within intensive care units. PsA bacteremia may be primary (with no identifiable source)
or secondary to a discrete focus of infection, including urinary and GI tract, lungs, skin and soft tissue, intravascular foci (e.g.
indwelling central venous catheters). The aim of this study is to assess clinical presentations and outcome of Pseudomonas bacteremia
in ICU patients, to assess risk factors for Pseudomonas bacteremia in ICU patients and to assess risk factors for emergence of MDR
Pseudomonas strains.
Method: All patients admitted to three ICUs (medical ICU, trauma ICU and surgical ICU) in Hamad General Hospital with positive
blood C/S for PsA over three years (1st Feb 2010-31st Jan 2013) were studied retrospectively. Patients having polymicrobial bacteremia
were excluded.
Results: Total number of patients was 47. Majority were males, most of the patientâ??s had comobrid conditions, prolonged hospital
stay and history of invasive procedures. Almost half of cases presented with septic shock. Outcome: All-cause mortality was about
60%, mainly because of primary disease. Rest of the patient were discharged home or shifted to rehabilitation units. Antimicrobial
susceptibility testing showed 14 out of 47 patients (29.7%) were MDR Pseudomonas. 4/47 (8.5%) were pan resistant, sensitive only to
Colistin. Colistin was 100% sensitive among all the isolates. Other susceptibilities were Amikacin 92%, Cefepime 82%, Ceftazidime
82%, Aztreonam 57%, Ciprofloxacin 88%, Gentamicin 86%, Meropenem 78% and Piperacillin Tazobactam 86%.
Conclusion: Prolonged hospital stay, presence of comorbid conditions, septic shock, immunosuppressive conditions and H/O
invasive procedures are poor prognostic factors in cases of Pseudomonal bacteremia. The previous history of antibiotics use lead to
emergence of multidrug resistant strains. Initiation of effective empirical antimicrobial therapy in patients at high risk of acquiring
pseudomonas infection can improve outcome.
E-mail: akashaf1@hamad.qa