Journal of Clinical & Experimental Dermatology Research
Open Access

Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo

Vitiligo and Skincare Physicians Meeting

September 15-16, 2016 Berlin, Germany

Lamia Elgarhy

Tanta University, Egypt

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Aim: To study immune histochemical expression of DDR1 in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis. Methods: 20 patients of non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from 10 healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression. Results: Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found. Conclusion: Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.

Biography :

Email: lamia_elgarhy@yahoo.com