Journal of Glycomics & Lipidomics
Open Access
ISSN: 2153-0637
+44 1223 790975
ISSN: 2153-0637
+44 1223 790975
Mahdieh Niknam
Shahid Beheshti University of Medical Sciences, Iran
Posters-Accepted Abstracts: J Glycomics Lipidomics
Atherosclerosis, with its major manifestation, coronary artery disease (CAD) is a chronic inflammatory disease. Dietary fatty acids intakes favorably effect on inflammatory responses. This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (ILâ�?�?6) and high sensitivity Câ�?�?reactive protein (hsâ�?�?CRP), in CAD patients among Iranian population. This hospitalâ�?�?based, crossâ�?�?sectional study was conducted in Chamran Heart Hospital, Isfahan, Iran in 2012. Patients aged â�?¥45 years with first ever symptomatic CAD confirmed by angiography were included. A semiâ�?�?quantitative food frequency questionnaire (FFQ) was used to assess the usual intakes of dietary fatty acids. The energyâ�?�?adjusted daily intakes (mean �?± SD) of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), linoleic acid, aâ�?�?linolenic acid, and eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) were 27 �?± 9, 22 �?± 6, 21 �?± 5, 0.4 �?± 0.32, and 0.85 �?± 0.82 g/d; respectively. After adjustment for potential confounders, SFA was directly related to hsâ�?�?CRP (P = 0.01) and ILâ�?�?6 (P < 0.001) concentrations. Intakes of EPA+DHA and MUFA, were significantly adversely related to plasma hsâ�?�?CRP concentration (P = 0.002 and 0.001, respectively) but not ILâ�?�?6, albeit MUFA was modestly inversely related to ILâ�?�?6 (P = 0.08). No significant relationships were observed for other fatty acids, aâ�?�?linolenic acid, and linoleic acid. These findings suggest that saturated fatty acids, EPA + DHA and MUFA were significantly related to plasma inflammatory markers in CAD patients.
Email: ma_niknam@yahoo.com