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Ata Saadat Sadeghi
Shahid Beheshti University of Medical Sciences, Iran
Posters & Accepted Abstracts: Appli Micro Open Access
Objectives: The increasing rate of antimicrobial resistance among A. baumannii species is a serious concern in treatment worldwide. Carbapeneme-hydrolyzing class D �?²-lactamases (CHDLs) encoded by OXA genes and some genetic elements like the insertion sequences (ISs) have an important role in resistance. The purpose of this study was to determine the antimicrobial susceptibility patterns and identify the OXA-carbapenemases genes and their related ISs that have an important role in drug resistance. Materials & Methods: In this experimental study, a total of 105 clinical isolates of A. baumannii were tested for their susceptibility to different antibiotics by using disc diffusion method as recommended by the CLSI (2014). Results: The susceptibility tests showed the high rate of resistance to all classes of antibiotics. Trimethoprim/sulfamethoxazole with rate 92.38% and minocycline and amikacin with 93.33% had a lower resistance to the others. Conclusions: In this current study, the presence of the ISs elements in clinical isolates can explain one of the major reasons for rapid transferring of resistance genes and the high prevalence rate of OXA genes. A. baumannii showed the necessity of controlling nosocomial infections and separating the patients with this infection especially from children and cancer patients.