Drug Designing: Open Access
Open Access

Design and synthesis of potential SRC inhibitors

International Conference and Expo on Drug Discovery & Designing

August 11-13, 2015 Frankfurt, Germany

Yu-Shan Wu1, Hsin-Chuan Kuo1, Yun-Jhen Hsieh1, I-Hua Lai2, Yung-Hao Wong2, Sih-Yin Lin2, and Jeremy J W Chen2

Scientific Tracks Abstracts: Drug Des

Abstract :

Src protein is an important signaling molecule in tumorigenesis and it plays a key role in the regulation of multiple cellular
mechanisms. An elevated Src activity has been found in many human tumors, especially in highly metastatic cancer such as lung
carcinoma. In an effort to search for efficacious Src inhibitors, both in silico virtual screening and in vitro screening methods were used
to identify possible lead compounds. We have synthesized three of these lead compounds from virtual screening and their inhibitory
activities are compared with the binding observed in computer docking. By simplifying the lead compound obtained from in vitro
screening, we have also designed and synthesized a series of analogs which would hopefully exhibit good Src inhibitory activity.

Biography :

Yu-Shan Wu has completed her from the Department of Chemistry, University of Cape Town and Postdoctoral studies from Academia Sinica as well as National Health
Research Institutes in Taiwan. She is currently an Associate Professor at Department of Chemistry, Tunghai University in Taiwan.