Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Ioannis Karagiannidis, Georgios Nikolakis, Martina Brunner and Christos Zouboulis
Dessau Medical Center, Germany
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
We report a case of an 83-year-old male, who presented to our departments with 3 red, painless nodes on the left shoulder, on the right flank and on the right abdominal area. He complained also for anorexia, progressive weight loss and difficulties in swallowing over one month, so that he was admitted to our hospital. Excision of the node on the right flank was performed and showed a non-small-cell formation in dermis and subcutaneous tissue with epithelioid cell clusters, atypia and prominent nucleoli. There was no clear squamous cell or adenoid differentiation. The Ki-67 labeling was 40%. The outer skin showed a normal epidermis. Immunohistochemically, the tumor cells were positive for CK5, CK6, p63 and vimentin. S100, Melan-A and CK20 were negative. The malignant tumor was located remote from the epidermis and skin appendages, so we suspected a metastatic nature. A diagnosis of a dedifferentiated, partly sarcomatoid squamous cell carcinoma, probably originating from the lung was made. Indeed, a computed tomography (CT) of chest, abdomen and pelvis showed except for a known preexisting pulmonary fibrosis, a tumor in the left lung with infiltration of the diaphragm. Moreover, several intrapulmonary lesions, peritoneal and mesenterial metastasis, several soft tissue metastases, a suspected cardial metastasis as well as a suspicious lymph node at the left lower mediastinum were detected. A lung biopsy was planned but the patient died due to a respiratory insufficiency. The present report underlines that sarcomatoid type of lung carcinoma, a rare and highly aggressive tumor should be considered in cutaneous metastatic lesions.