Drug Designing: Open Access
Open Access
ISSN: 2169-0138
ISSN: 2169-0138
Mohamed Hamdy Ibrahim, Alyaa Fadhil, Sameh Saied Ali, Salma Fathy Abdel Kader, Mohamed Khalid and Kiran Kumar
Gulf Medical College Hospital & Research Centre, UAE
Posters & Accepted Abstracts: Drug Des
Background: Focal dystonia in young aged patients considered to be uncommon clinical presentation, unless a secondary cause to be considered. Infarcts of the corpus callosum are rare and have not been well documented previously. As for a variety of signs and symptoms due to corpus callosum lesion, Focal dystonia can be easily overlooked. Introduction: The clinical manifestation of the acute corpus callosum infarction is lack of specificity and complex because it often merger with other location infarction. Thus, it is easily missed diagnosis and misdiagnosis in the early stage. With the widespread application of nuclear magnetic resonance (NMR), its diagnostic rate is much higher. Case presentation: A male patient 19 years old, dental student presented to the neurology clinic by sudden onset of dystonic posturing in the trunk with flexion of the trunk on speaking and frequent spontaneous myoclonic jerks at rest, continue during sleep too. General examination showed no abnormalities, Neurological examination showed, dystonia and frequent myoclonic jerks, staccato speech, dysphagia to fluids. With no other cranial nerves abnormalities Patient was hospitalized, MRI brain and MRA showed acute splenium of corpus callosum infarction, ECHO cardiography was done to detected cardiac source of infarction and it showed him to have normal ECHO findings. CBC and protein S and C are normal. Findings: Patient was advised to go for transesophageal ECHO and Antithrombin III level in blood. During hospitalization, he was given the followings; Clonazepam 1mg every 12 hours, lamotrogine 100 mg/12 hours, levodopa 12.5 mg half tablet every 12 hours, clopidogrel 75 mg/24 hour. Patient showed dramatic improvement as regard the involuntary movements. Conclusions: The corpus callosum infarction is lack of typical symptoms and signs because it often occurs with other cerebral ischemic lesion. It is reminded of callosal infarction when the patient has consciousness or cognitive change, apraxia, such as alien hand syndrome with mild paralysis. The patients are at higher risk of stroke and the main risk factors are carotid intima thickening or plaque formation, hypertension, hyperlipidemia and the cerebral artery stenosis. The hemodynamic disorder after the cerebral large vascular lesions may be the main pathogenesis. TCD and cervical Doppler ultrasound examination can found early hemodynamic disorder to guide the prevention and treatment.