Journal of Fundamentals of Renewable Energy and Applications
Open Access
ISSN: 2090-4541
ISSN: 2090-4541
Sameer P Khare, Parminder Kaur, Alexei Lapkin, Davide Mattia1 and Pawel Plucinski
Chemica University of Bath, UK
University of Cambridge, UK
Posters & Accepted Abstracts: J Fundam Renewable Energy Appl
Ozonolysis reaction of monoterpene hydrocarbons has been demonstrated in a continuous flow process using micro-reactor technology. Current work reports the conversion of terpenoid feedstock (b-pinene) to nopinone, an intermediate product towards production of active pharmaceutical ingredient (API). The gas-liquid reaction with liquid flow of 0.5-1 ml/min in flow micro reactor with high product selectity (>85%) is successfully demonstrated at room temperature (250C) as opposed to -780C in batch. Parametric evaluation of feed concentration, operating temperatures, gas/liquid ratios on conversion and product selectivity is reported for process optimization. The risk of potential thermal run-away scenario while performing exothermic reaction and production of explosive ozoides, peroxides and toxic reagents were mitigated by utilizing the small volume micro-reactor technology. The gPROMS process model is formulated as a two-phase gas-liquid flow reaction operating in Taylor flow and corresponding kinetic parameters were estimated and validated with the experimental results. The reaction is very fast with residence time of ~1 sec. An experimental evaluation of product separation and purification using membranes is also reported with 95% separation performance.
Email: s.p.khare@bath.ac.uk