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Krystyna Mojsiewicz Pienkowska, Katarzyna Szymkowska, Dominika Glamowska,Krzysztof Cal, Zbigniew Jankowski, Marzena Jamrógiewicz, Rafa�? Bartoszewski, Sylwia Bartoszewska and Micha�? Piku�?a
ScientificTracks Abstracts-Workshop: J Clin Exp Dermatol Res
Skin diseases and dermatology problems depend on many factors. One of the reasons could be the influence of various substances presence in medical products on skin, personal care products or cosmetics which are not indifferent for skin. The reason can be changing of the skin barrier by active pharmaceutical ingredients API or excipients. A new interdisciplinary approach is presented to demonstrate possibility of penetration of the low molecular linear and cyclic methyl siloxanes (silicones) to human stratum corneum and permeation to the deeper layers of the skin (epidermis and dermis). On the basis of the fluorescence microscope as well as ATR FT-IR spectroscopy both the penetration and permeation to this skin layer as well as impact on the damage of corneocytes of the stratum corneum was observed. Presented results show that the phenomenon alteration the skin barrier was due to the damage of stratum corneum structure in conjunction with distinct disturbances in the lipid structure of the mortar lipid of the stratum corneum. It is noticed that cyclic and linear methyl siloxanes are able to overcome the barrier of the skin due to the interaction between silicones and SC lipids bilayers. Obtained results concerning the cytotoxic effects for immortal keratinocytes cell line HaCaT are also presented. These conclusions are very important, particularly in dermatology and toxicology, to the safety assessment of using these compounds. Low molecular linear and cyclic methyl siloxanes are commonly used as excipients in medical products for skin (e.g. Rozex Metronidazolum) and personal care products (e.g. Penaten Baby Cream or Body Lotion Garnier). It causes the significant human exposure to this group of compounds. They can be applied both by adults, children and infants. It must be noticed that so far, the transdermal route has not been described in the literature as a possible route of penetration and permeation by the linear and cyclic methyl siloxanes.
Krystyna Mojsiewicz-Pienkowska PhD, D.Sc. is an Assistant Professor in the Department of Physical Chemistry at the Medical University of Gdansk, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Gdansk, Poland. She is also an expert in the National Centre for Research and Development. She has published more than 25 papers in reputed journals. Krystyna Mojsiewicz-Pienkowska is an active reviewer for the scientific pharmaceutical and chemical journals. Currently scientific and research activity is related with: studies of the penetration and permeation of silicones and drugs through the human skin; development of analytical methods for drug analysis; silicones application in pharmacy, medicine and cosmetic products.