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Clinical characteristics, laryngeal dysplasia and HPV genotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis: A prospective observational study in Northeastern Mexico
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

Clinical characteristics, laryngeal dysplasia and HPV genotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis: A prospective observational study in Northeastern Mexico


International conference on Human Papillomavirus

October 20-21, 2016 Chicago, USA

Gerardo C. Palacios-Saucedo, Cristina R. Perez-Espejo, Lydia G. Rivera-Morales, Gustavo I. Amador-Patino, Julio C. Serna-Hernandez, Silvia J. Hernandez- Martinez, Erika Espindola-Salgado, Jose M. Vazquez-Guill?©n, Rocio Ortiz-Lopez, Cristina Rodriguez-Padilla

Unidad M?©dica de Alta Especialidad No. 25 Instituto Mexicano del Seguro Social,
Facultad de Ciencias Biol?³gicas Universidad Aut?³noma de Nuevo Le?³n,
Facultad de Medicina and Centro de Investigaci?³n y Desarrollo en Ciencias de la Salud Universidad Aut?³noma de Nuevo Le?³n, NL, M?©xico

Scientific Tracks Abstracts: J Antivir Antiretrovir

Abstract :

Objective: To evaluate the clinical characteristics, presence and severity of laryngeal dysplasia and human papilloma virus (HPV) genotypes in patients with juvenile-onset recurrent respiratory papillomatosis (JORRP) in a tertiary care facility in Northeastern Mexico. Design: A prospective observational study in patients with JORRP who underwent biopsy by suspension microlaryngoscopy. Setting: A single tertiary care unit with pediatric and adult otolaryngology services in Northeastern Mexico. Participants: Thirty patients with JORRP. Main outcome measures: Clinical data, number of surgical resections, presence and severity of dysplasia, and HPV genotypes as determined by the reverse linear hybridization INNO-LiPA assay. Results: Median age at presentation was 3.5 years (range 8 months to 17 years), 22 patients were females (73.3%) and 8 males (26.7%). The main symptom was dysphonia (53.3%) and the total number of resections per patient ranged 2 to 550 (median 15.5). Dysplasia was identified in 13 patients (43.4%). The most frequent genotypes were HPV-11 (40%) and HPV-6 (36.7%). Co-infection with two or three genotypes was detected in seven patients (23.3%), including the genotype HPV-16 in four of them (10%). Conclusions: Patients with JORRP experienced a significant delay in establishing the diagnosis, required multiple surgical resections, and had a high rate of laryngeal dysplasia. The most common HPV genotypes were 11 and 6, followed by HPV-16. This is the first study in Mexico evaluating clinical characteristics, dysplasia severity and HPV genotypes in patients with JORRP.

Biography :

Dr. Gerardo C. Palacios-Saucedo completed his M.D. degree from the Universidad Autonoma de Coahuila, Mexico and completed his Ph.D. from the Universidad Autonoma de Nuevo Leon, Mexico. He is Head of the Health Research Division and Titular B Researcher in the Hospital de Especialidades No. 25 Instituto Mexicano del Seguro Social in Monterrey, and Level II National Researcher by the Consejo Nacional de Ciencia y Tecnología Mexico. He has published 68 papers, most in indexed and high impact journals.

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