Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Woo Seung Yang, Jin Bae Weon, Gahee Ryu and Choong Je Ma
Kangwon National University, Korea
Posters & Accepted Abstracts: Med Aromat Plants
Clematis mandshurica (C. mandshurica) is a traditional crude drug for treatment of urethritis, carbuncles and carcinoma. The objective of this study was to confirm the cognitive enhancing effect C. mandshurica using two behavioral tests, Morris water maze test and passive avoidance test. 50, 100 and 200 mg/kg of C. mandshurica extract were administered to mice. We also investigated acetylcholinesterase (AChE) activity and brain-derived neurotropic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation in scopolamine-induced memory deficit on mice to determine possible mechanism. The results revealed that C. mandshurica attenuated learning and memory impairment by scopolamine. C. mandshurica also inhibited acetylcholinesterase level in hippocampus of scopolamine-injected mice. Moreover, C. mandshurica increased BDNF and p-CREB expression in hippocampus. These results indicated that C. mandshurica improved memory impairment through AChE inhibition and BDNF and p-CREB expression and suggesting that C. mandshurica could be a useful therapeutic agent for the prevention or treatment of Alzheimer��?s disease.
Woo Seung Yang has done his Master’s degree in Department of Medical Biomaterials Engineering, College of Biomedical Sciences, Kangwon National University, Korea. His has done his Major in Pharmacognosy.
Email: diddntmd11@gmail.com