Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ortega-Alonzo S E, Portillo-Palma P A, Rubio-Perez N E and Rodriguez-Perez M L
Monterrey Institute of Technology and Higher Education, M�©xico
Posters & Accepted Abstracts: J Clin Cell Immunol
Background: Systemic Lupus Erythematosus (SLE) is a chronic, inflammatory and autoimmune disease with multi-systemic involvement. Children represent 10-20% in the general population and neuropsychiatric symptoms have a prevalence of 17-70%. Objective: Objective of the study was to describe the clinical presentation and neurological manifestations in a pediatric patient with SLE. Methods: We present the case of a 15 year female with 3 week history of movement disorder, dysarthria and emotional liability. Laboratory and imaging studies were performed and a diagnosis of Sydenham�s chorea was established. Following 4 weeks of treatment, she developed arthritis and aphasia. Results: Radiologic evaluation did not show any disturbances, general laboratories were normal, immunological profile reported anti-nuclear antibodies with a title of 1:640, fine speckled pattern, and lupus anti-coagulant reported 2.18. Conclusion: Diagnostic evaluation of SLE in children represents a challenge due to its clinical heterogeneity; the time related to adding signs during life and the wide severity of symptoms among pediatric population. Neurologic and psychiatric manifestations represent one common and severe evolution in SLE. Choreic movements occur in less than 5% of patients and may precede the accurate diagnosis for months and years, before the development of the whole clinical picture.
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