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Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance
Journal of Glycomics & Lipidomics

Journal of Glycomics & Lipidomics
Open Access

ISSN: 2153-0637

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance


International Conference on Lipid Science & Technology

November 30 - December 02, 2015 San Francisco, USA

Kavitha Thirumurugan, Mohamed Sham Shihabudeen, Debasish Roy and Joel James

VIT University, India

Posters-Accepted Abstracts: J Glycomics Lipidomics

Abstract :

Adipose tissue secretes adipokines that regulate insulin sensitivity in adipocytes and other peripheral tissues critical to glucose metabolism. Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue. The role of Farnesoid X receptor (FXR) activation on adipokines in relation to adipose tissue inflammation and insulin resistance is not completely explored. For the first time, we have evaluated the ability of Chenodeoxycholic acid (CDCA), an endogenous FXR ligand, in restoring the disturbance in adipokine secretion and insulin resistance in palmitate treated 3T3-L1 cells and adipose tissues of high fat diet (HFD) rats. CDCA suppressed several of the tested pro-inflammatory adipokines (TNF-├?┬▒, MCP-1, IL-6, Chemerin, PAI, RBP4, resistin, vaspin), and enhanced the major anti-inflammatory and insulin sensitizing adipokines (adiponectin, leptin). CDCA suppressed the activation of critical inflammatory regulators such as NF-├?┬║B and IKK├?┬▓ which are activated by palmitate treatment in differentiated cells and HFD in rats. We show the altered adipokines in insulin resistance, its association with inflammatory regulators, and the role of CDCA in amelioration of insulin resistance by modulation of adipokines.

Biography :

Email: [email protected]

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