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Chemical constituents and their cytotoxicity from the roots of Dalbergia velutina
Medicinal & Aromatic Plants

Medicinal & Aromatic Plants
Open Access

ISSN: 2167-0412

Chemical constituents and their cytotoxicity from the roots of Dalbergia velutina


3rd Global Summit on Herbals & Traditional Medicine

October 18-20, 2017 Osaka, Japan

Sutin Kaennakam

Chulalongkorn University, Thailand

Posters & Accepted Abstracts: Med Aromat Plants

Abstract :

Three new pterocarpans, velucarpins A-C and two new isoflavanes, dalvelutinanes A-B along with six known compounds were isolated from the roots of Dalbergia velutina. Their chemical structures including absolute configurations were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS and CD). All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, MCF-7, HepG-2 and HT-29). Compound 10 showed good cytotoxicity against all the five cancer cell lines with IC50 values in the range of 3.47-9.76 ├?┬ÁM. In addition, compound 3, 7 and 9 showed good cytotoxicity against KB and HeLa S-3 cells with IC50 values in the range of 5.99-9.54 ├?┬ÁM and compound 5 showed good cytotoxicity against MCF-7 cell with IC50 value of 4.69 ├?┬ÁM.

Biography :

Sutin Kaennakam has completed his PhD from Chulalongkorn University in Thailand and Postdoctoral studies from Natural Products Research Unit, Department of Chemistry, Faculty of Science of Chulalongkorn University, Thailand. He has published more than 8 papers in reputed journals.

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