Orthopedic & Muscular System: Current Research
Open Access
ISSN: 2161-0533
+44-20-4587-4809
ISSN: 2161-0533
+44-20-4587-4809
Ashley L Bui, Michael A Lopez, Muhaimeen Hossain and James J Hickman
Posters-Accepted Abstracts: Orthop Muscular Syst
Biological micro electromechanical systems (bio-MEMS) have been engineered to replicate animal and human tissue in order to develop body-on-a-chip systems. These models are beneficial for drug development by allowing a non-invasive acquisition of cellular electrophysiological response as well as reducing ethical concerns found in traditional animal and human trials. As these systems become smaller and more intricate, the accurate positioning of droplets containing biological components onto bio-MEMS becomes more difficult. The use of a cellular bioprinter allows the user to quickly deposit micro droplets with high precision. Multiple cell types are also easily printed onto a single microchip enabling integrated cell studies. We have optimized the printing process to reliably print skeletal muscle and neurons onto silicon-based bio-MEMS for the development of in vitro tissue platforms to study various physiological disorders.