Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Thi Vinh An Do
Hematology and Blood Transfusion Center, Bach Mai Institute, Vietnam
Scientific Tracks Abstracts: J Hematol Thromb Dis
According to WHO 2016, multiple myeloma is a hematologic malignancy, usually in the bone marrow with an increase of more than 10% of plasma cells, with morphological identifications, immunological markers and chromosomal abnormalities. Peripheral blood has abnormal immunoelectrophoresis, rouleaux formation, high level of LDH with lytic bone lesions in MRI. Anaplastic cell myeloma is a rare, refractory subtype of multiple myeloma and has a poor prognosis. However, abnormal morphology and asynchronous immunophenotypic expression of plasma cell can be seen in newly diagnosed cases of multiple myeloma and often cause the inaccuracy of initial diagnosis. CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered as the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 marker in plasma cells. Herein we present a rare case of CD38-negative multiple myeloma that was initially misdiagnosed as acute leukemia
Thi Vinh An Do is a Lecturer in Biology Department of Hanoi National University, Lecturer at Bach Mai Medical College. She is working at Hematology and Blood Transfusion Center, Bach Mai Institute, Hanoi, Vietnam. With 26 years of professional experience, she has contributed to many assessments in many national conferences and chaired many valuable Scientific Research projects