Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
ISSN: 2329-8790
Thi Vinh An Do
Bach Mai Institute, Vietnam
Scientific Tracks Abstracts: J Hematol Thromb Dis
CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 marker in plasma cells after chemotherapy treatment. Herein we present a rare case of CD38-negative multiple myeloma that was initially misdiagnosed as acute leukemia. Introduction: According to WHO 2016, multiple myeloma is a hematologic malignancy, usually in the bone marrow with an increase of more than 10% of plasma cells, with morphological identifications, immunological markers, and chromosomal abnormalities. Peripheral blood has abnormal immunoelectrophoresis, rouleaux formation, high level of Lactate dehydrogenase (LDH) with lytic bone lesions on MRI. Anaplastic plasma cell myeloma is a rare, refractory subtype of multiple myeloma and has a poor prognosis. However, abnormal morphology and asynchronous immunophenotypic expression of plasma cells can be seen in newly diagnosed cases of multiple myeloma and often cause the inaccuracy of initial diagnosis. Case Presentation: A 46-year-old female patient with unsignificant past medical history presented with fatigue and dyspnea for the previous three months. The physical examination was unremarkable. ENT endoscopy showed a mass in the nose, histopathology of the biopsy piece of this tumor revealed nasopharyngeal cancer.
Dr. Thi Vinh An Do is a Lecturer in Biology Department of Hanoi National University, Lecturer at Bach Mai Medical College. She is working at Hematology and Blood Transfusion Center, Bach Mai Institute, Hanoi, Vietnam. With 26 years of professional experience, she has contributed to many assessments in many national conferences and chaired many valuable Scientific Research projects.