Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
+44 1300 500008
ISSN: 1948-5964
+44 1300 500008
Zil-e-Rubab
Ziauddin University, Pakistan
Posters-Accepted Abstracts: J Antivir Antiretrovir
Background: In Pakistan, oropharyngeal cancer is the second leading malignancy attributed to the extensive use of smokeless tobacco products. In many studies, the high risk genotypes of HPV are proven to play a key role in oral squamous cell carcinoma (OSCC).There is a considerable diversity in the epidemiology of high risk HPV genotypes in different countries. Aim: The objective of this study was to find out the association between high risks HPV genotype in oral rinse of patients with OSCC and pre malignant oral lesions. Methods: In this case-control study, 200 samples of oral rinse were analyzed by PCR. A significant association between HPV and OSCC was found (OR=3.14, 95% CI=1.6750-5.8969, P value=0.0004). Results: There was positive association between presence of both HPV 16/18 and OSCC but it was not significant possibly due to small sample size (OR=3.2381, 95% CI=0.8208-12.7752, P value=0.0934). Conclusion: As a result of these findings, HPV and predominantly genotypes 16 and 18 may be associated with the development of OSCC in Pakistan.
Email: zile_rubab@hotmail.com