Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Association between TNFSF15 polymorphism and ulcerative colitis in Iranian population

6th International Conference and Expo on Immunology

October 24-26, 2016 Chicago, USA

Marzieh Taheri, Pegah Ghandil, Seyyed Jalal Hashemi, Abdol Rahim Masjedizadeh, Mehri Ghafourian and Ata Allah Ghadiri

Ahvaz Jundishapur University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Ulcerative colitis (UC) is the most prevalent form of the inflammatory bowel disease. Several candidate genes have been suggested to be involved in the genetic susceptibility or resistance in development of UC. Tumor necrosis factor ligand super family member 15 (TNFSF15) have been recently reported in association with UC. This is a transmembrane protein that has multiple functions such as: Proliferation, apoptosis and expression of inflammatory genes. The aim of this study was to investigate the association of TNFSF15 single nucleotide polymorphism (SNPs) in the promoter region, including rs6478108 (G/A-9706) in Iranian patients with ulcerative colitis. The SNP were genotyped in 115 cases and 115 healthy controls from the same ethnic and geographical region, located in Khuzestan province, Iran. The DNA of samples was genotyped using TaqMan Real time PCR assays. The results did not confirm the formerly reported association of the studied polymorphisms with UC disease neither with the type of the clinical forms of colitis. Since multiple ethnic groups resides in all around the country, further analyses in different ethnicities are required with larger sample size to clarify the role of this polymorphism in the genetic susceptibility of UC in Iranian populations.

Biography :