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Assessment of skin and eye irritation of 14 products under the st | 715
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

Assessment of skin and eye irritation of 14 products under the stepwise approach of the OECD


2nd International Conference on Clinical Research Cardiology, Ophthalmology & Dermatology

5-7 March 2012 Omaha Marriott, USA

Axel Mancebo, Osvaldo Hern�ndez, Yana Gonz�lez, Lizet Aldana and Onelio Carballo

Posters: J Clin Exp Dermatol Res

Abstract :

The determination of acute eye and skin irritation is included in international regulatory requirements for the testing of chemicals, due to the possibility of exposure during the production, transport, marketing, and disposal of products. Although has been some advances on the areas of refinement and reduction, no single battery of tests has emerged as being acceptable as a complete replacement for the conventional Draize rabbit eye and skin irritation tests. Currently, the dermal and ocular irritation are generally assessed in a sequential manner in the context of tiered assessment strategies. In this work, we show how 14 products, mostly designed to be used in the agriculture, were evaluated in the Center of Experimental Toxicology of CENPALAB in order to assess its acute dermal and ocular effects. The performed studies include the acute dermal toxicity, the acute dermal irritation/corrosion, the hen?s egg test- chorioallantoic membrane (HET-CAM) method, and the acute eye irritation/corrosion, and. In general, it could be concluded that of the 14 products assessed, none of them showed systemic effects, but local reactions mainly to eyes. The most significant effects were apparently related to the effects of Azadirachtin, active principle of two tested Neem derivatives.

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