Jaehyuk Choi, Jae-Wook Hyun, Hyun-Joo An and Kwang-Hyun Baek
Yeoungnam University, South Korea
Citrus Research Station, South Korea
Posters & Accepted Abstracts: J Drug Metab Toxicol
Citrus canker caused by Xanthomonas Citri Subsp. Citri (Xcc) decreases the fruit quality and yield significantly. Emerging of Streptomycin-Resistant (SR) strains threatens the citrus industry seriously because of a lack of proper control agents. It has been suggested that ssAMPs could be a promising alternative. Over 50 potential hexapeptides were designed and synthesized based on the Positional Scanning of Synthetic Peptide Combinatorial Libraries (PS-SPCL). Majority of them showed antimicrobial activities against variety of microbes including Bacillus, Pseudomonas, Xanthomonas and Candida species. Three hexapeptides, BHC06 and 11, and KCM21 were selected and tested to control citrus canker using 5 years old sathuma mandarin leaves (Citrus unshiu). Each hexapeptide drastically reduce the canker symptom development caused by wild type as well as SR strains. The results showed great potential of ssAMPs to fight against emerging antibiotics-resistant pathogens in agriculture.
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