Immunome Research
Open Access
ISSN: 1745-7580
+44-20-4587-4809
ISSN: 1745-7580
+44-20-4587-4809
Reyhaneh Sariri, Zahra Derakhshan and Seiedhabib Zaieni
University of Guilan, Iran
Guilan University of Medical Sciences, Iran
Posters & Accepted Abstracts: Immunome Res
A typical autoimmune disease with chronic systemic inflammation is systemic lupus erythematosus (SLE). The pathogenesis of SLE includes a number of internal and external factors. However, it is suggested that oxidative stress may play an important role in this regard. Therefore, either increase of Reactive Oxygen Species (ROS) or impaired antioxidant defense system can cause oxidative stress in SLE. We have previously studied variations in antioxidant activity in serum of SLE patients. To the best of our survey, however, salivary antioxidant enzymes have not been evaluated. Saliva, the non-invasive biological fluid, could be a reflection of the state of health. Therefore, the purpose of this study was evaluation of peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) activity in the saliva of patients with SLE. In practice, 30 patients with SLE and 30 healthy controls were selected to enter the research and donate their saliva samples. Their un-stimulated saliva was centrifuged and the biological activity of POD, CAT and SOD were evaluated and the results were statistically analyzed. According to the results, the biological activities of antioxidant enzymes SOD and CAT were significantly reduced in saliva of SLE patients as compared to controls. It is suggested that antioxidant status is impaired in the saliva of SLE patients and antioxidant status of saliva could be one of the non-invasive markers for SLE.
Email: sariri@guilan.ac.ir