Antimicrobial and antioxidant evaluation of hydroxylated hydroxam | 11637
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

+44 1300 500008

Antimicrobial and antioxidant evaluation of hydroxylated hydroxamic acid from underutilized Adansonia digitata seed oil

Joint Event on 4th International Conference on Antimicrobials, Multiple Drug Resistance & Antibiotics Resistance & 4thInternational Conference on Antibiotics R&D, B2B

April 20-21, 2018 Las Vegas, USA

Adewale Adewuyi, Fabiano Vargas Pereira and Rotimi Ayodele Oderinde

Redeemer��?s University, Nigeria
Federal University of Minas Gerais, Brazil
University of Ibadan, Nigeria

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Hydroxylated fatty hydroxamic acid (ADX) was synthesized from underutilized Adansonia digitata seed oil (AD). The synthesis was monitored using Fourier Transform Infrared spectrometer (FTIR) and Nuclear Magnetic Resonance (1H NMR). ADX was characterized using X-ray Diffraction analysis (XRD), Scanning Electron Microscopy (SEM), particle size distribution (PSD), zeta potential and Thermogravimetric Analysis (TGA). ADX was further screened for its antimicrobial activity against certain Gram positive and Gram negative pathogenic organisms as well as it potential as antioxidant agent. The result revealed the most abundant fatty acid in AD to be C18:1 (36.55%). The 1H NMR confirmed the production of ADX with corresponding peaks. The PSD of ADX was monomodal with a mean size of 0.0541 �?µm while the zeta potential increased as pH increased. ADX exhibited antimicrobial activity against the test organisms except E. coli and Salmonella enteritidis with the highest activity against Staphylococcus aureus (28mm). ADX also had an appreciable in vitro antioxidant activity due to its capacity to scavenge DPPH (1,1-Diphenyl-2-picryl-hydrazyl) radical (IC50 of 389.12ppm). The present study suggests ADX as a promising antimicrobial and therapeutic agent for scavenging free radicals.