Journal of Clinical and Cellular Immunology
Open Access

Antigen-microarray profiling of antibodies in SLE: A personal view of translation from basic science to the clinic

3^rd International Conference on Autoimmunity

November 26-27, 2018 | Dublin, Ireland

Irun R Cohen

Weizmann Institute of Science, Rehovot, Israel

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

In October of 2015, the startup company ImmunArray announced the launch of a microarray platform�??the iChip® to profile repertoires of serum antibodies and autoantibodies. The first iChip® product�??the SLE-key® Rule Out test is designed to help the physician rule out a diagnosis of systemic lupus erythematosus (SLE) in suspected patients. The aim of this review is threefold: the first aim is to describe how basic observations and a philosophical notion led the author to undertake the development of what has turned out to be a clinically useful aid in dealing with complex diseases; the second aim is to describe the role of a company in overcoming the technological and informatics challenges involved in translating basic research into patient welfare; the third aim is to discuss why SLE, like other complex medical problems, can be better managed using immune profiling. Basic scientist readers might learn here about the path to clinical application; clinician readers might learn here about the complicated origins of seemingly simple tests.

Biography :

E-mail: irun.cohen@weizmann.ac.il