Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Bing Xie and Yinglong Su
East China Normal University, China
Posters & Accepted Abstracts: J Drug Metab Toxicol
The abuse of antibiotics caused the widespread of antibiotic resistome, which further raised the issue on public health. Leachate, generated during the landfill treatment of municipal solid waste, is the important hotspot of the antibiotics and Antibiotic Resistance Genes (ARGs) and no effective on-site treatment has been put forward for preventing ARGs dissemination until now. Herein, the aged refuse bioreactor was employed to remove antibiotics and ARGs from leachate, and the great removal performance was observed. For the detected antibiotics, the total removal efficiency was about 76.75%, and sulfanilamide and macrolide were removed with high efficiencies (>80%). Among the target ARGs, tetracycline and macrolide resistance genes (tetM, tetQ and ermB) were eliminated with 1.2-2.0 orders of magnitude. Mechanism study indicated that the occurrences of ARGs did not correlated with physicochemical parameters, but closely linked to the variations of the bacterial community structure. Network analysis revealed the potential host bacteria of ARGs in leachate, and redundancy analysis indicated the significant correlations between four genera and the distribution of ARGs, which implied that these key genera (including potential pathogens) drove the ARGs removal. Furthermore, the hydraulic loading test confirmed that the aged refuse bioreactor was capable of achieving high removal efficiencies even under shock loading for the higher loading was negative for the proliferations of potential ARGs hosts. This study suggested that the aged refuse bioreactor could be a promising way for antibiotics and ARGs on-site removal from leachate.
Email: bxie@des.ecnu.edu.cn