Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
ISSN: 2157-7609
Hoai Nguyen, Van BT Nguyen and Thuc T Nguyen
HCMC International University, Vietnam
Posters & Accepted Abstracts: J Drug Metab Toxicol
The increase of community-associated and hospital-acquired infections with Staphylococcus aureus accompanying with the raise of antibiotic resistant isolates particularly multi-drug resistant (MDR) ones recently has become a serious clinical and epidemiological problem. In this study, 51 S. aureus isolates obtained from healthy volunteers in Southern Vietnam were analyzed in order to determine their drug susceptibility to twelve commonly used antibiotics including ampicillin, cefoxitin, chloramphenicol, ciprofloxacin, clindamycin, erythromycin, kanamycin, linezolid, meropenem, rifampin, tetracycline and trimethoprim/ sufamethxazole by using disc diffusion technique. The resistant rate of S. aureus isolates to vancomycin was also determined by using minimum inhibitory concentration method. Antibiotic sensitivity test demonstrated that most of the isolates were resistant to ampicillin (96.08%). Meanwhile the resistant rates to clindamycin, kanamycin, erythromycin, linezolid, tetracycline and ciprofloxacin were in the range of 28%-61%. In addition, few antibiotics still have strong effect on S. aureus such as cefoxitin (resistant rate- 15.69%), meropenem (13.73%) chloramphenicol (5.88%), trimethoprim/sufamethxazole, rifampin (1.96%) and particularly vancomycin (0%). Moreover, the rate of MRSA in southern Vietnam community is estimated via cefoxitin resistant percentage which is around 16%, doubled the rate announced in 2004. In conclusion, the data provided essential information on the antibiotic susceptibility profile of S. aureus isolates in Vietnamese community.
Email: ntthoai@hcmiu.edu.vn