Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Meshref Ali Al Amri, Abdulrahman K Al Asmari, Abdul Quaiyoom Khan and Rajamohamed Abbasmanthiri
Prince Sultan Military Medical City, KSA
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Scorpion venom is a complex mixture of biologically active moieties with promising therapeutic values such as tools for drug development. Present study was designed to elucidate the anti-cancer potential of the crude venom extracted from the medically important scorpion Androctonus bicolor against two-stage mouse skin cancer model. Animals were divided into five groups (I-V) of 10 animals each. Animals of group first were given vehicle (acetone) only. 7,12-Dimethylbenz[a]anthracene (DMBA, 400 nmol/mouse) was applied to the animals of the groups (II-V) to initiate the process of carcinogenesis. One week after DMBA application promoting agent croton oil (1%) was applied to the animals of the groups (II-V). A. bicolor venom at different concentrations (12.5, 25, 37.5 �?¼g/animal) was given to the animals of group III-V half an hour prior to the croton oil application. All the treatment was given topically. Results of the current study revealed that A. bicolor venom inhibits DMBA initiated and croton oil promoted skin tumorigenesis in terms of tumor incidence and tumor multiplicity. Expression level of TNF-�?± and MPO was also suppressed by venom treatment. Furthermore, cutaneous expression of Ki-67 and NF-�?ºB and histological changes were also attenuated by A. bicolor venom. In conclusion, findings of the current study demonstrate the anti-tumorigenic potential A. bicolor venom which may provide a novel and effective template for the development of anticancer moieties.
Meshref Ali Al-Amri has completed his Master’s degree in Drugs and Toxicology Science from King Saud University and his Bachelor’s degree in Pharmaceutical Sciences from the same university. He is the Assistant Director General of Academic Affairs in Medical Services Directorate of Armed Forces, Ministry of Defense, Riyadh, Saudi Arabia. He has published number of papers in reputed journals. He is associated with several ongoing projects on skin cancer study in in vivo as well as in vitro.