Immunome Research
Open Access
ISSN: 1745-7580
ISSN: 1745-7580
Shiju Chen, Yangchun Chen and Guixiu Shi
The First Affiliated Hospital of Xiamen University, China
Posters & Accepted Abstracts: Immunome Res
The acute gouty arthritis (GA) is one most painful acute inflammation induced by monosodium urate (MSU) deposition. The pathogenesis of inflammation remains unclear. Activation of MyD88/ NF-kB signal pathway is involved in acute GA, giving rise to the increase of cytokines including TNF-, IL-1, and IL-6. MicroRNAs(miRNAs), severing as post-transcriptional regulation, is reported to participate in many inflammatory diseases including acute GA. Previous study demonstrated miR920 down-regulated in the peripheral white blood cells of GA which negative regulated target IL-1�?�?. This may be the role of miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of GA. To further explore the function of miR-920 in acute GA, we detected miR-920 by qRT-PCR in the peripheral blood mononuclear cells (PBMCs) of 9 acute gouty arthritis patients and 9 healthy controls. However, overexpression of miR-920 was found in PBMCs and MyD88 was predicated as another target gene by bioinformatics. After transfecting the miR-920 mimics or negative control mimics into human monocytic THP-1 cell line, expression of MyD88 decreased. This may hint an opposite role of miR-920 in acute gouty arthritis. Recent Publications 1. Chen S, Liu Y, Shi G (2014) Anti-CD20 antibody in primary Sjogren's syndrome management. Curr Pharm Biotechnol. 15(6): 535-541. 2. Zhou M, Ma J, Chen S, Chen X, Yu X (2013) Pulsed electromagnetic field stimulates osteoprotegerin and reduces RANKL expression in ovariectomized rats. Rheumatology International. 33(5): 1135-1141. 3. Zhou M, Ma J, Chen, S (2013) MicroRNA-17-92 cluster regulates osteoblast proliferation and differentiation. Endocrine. 45(2): 302-310. 4. Liu Y, Chen S, Sun Y, Lin Q, Liao X et al. (2016) Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: a retrospective study. Medicine (Baltimore) 95(50): e5565. 5. Liu Y, Liao X, Wang Y, Chen S, Sun Y, Lin Q, Shi G (2017) Autoantibody to MDM2: A potential serological marker of primary Sjogren's syndrome. Oncotarget. 8(9): 14306-14313.
Shiju Chen has her experience in diagnosis and treatment of rheumatoid diseases and clinical research. She has been engaged in busy clinical work for a long time and keeps a great passion and interest in dealing with patents and their diseases. She has some experience in osteoporosis and osteoarthritis disease in basic and clinical research including Wnt/beta - catenin signaling pathway and mi-RNA regulation function in the osteoblast. Now the main research focus on microRNAs and exosome in inflammatory arthritis.
Email:csj850815@126.co