Journal of Psychology & Psychotherapy
Open Access

Accession to persona load and mind-approach under the of trauma with pharmaceuticals

Joint Event on 24^th International Conference on psychiatry & psychosomatic medicine & 2^nd International Congress on forensic science and psychology

October 12-14, 2017 London, UK

Toshiko Sawaguchi, Toshihiro Sugiyama, Tomohisa Mori and Sung Kim

National Institute of Public Helath, Japan

Posters & Accepted Abstracts: J Psychol Psychother

Abstract :

It is important how to access persona and mind for medical and health care particularly under the load of trauma. Here the possibility of two approaches was introduced recently in Japan: 1) Decreasing pharmaceuticals usage for psychotherapy for multiple personality disorders. The ego state therapy was a treatment procedure for multiple personality disorders. If EMDR is not effective, the parallel treatment of ego state therapy might be effective. For complex PTSD cases, refractory mood swings could be better with a very small amount of lithium carbonate (1 mg - 3 mg) and a very small amount of antipsychotic aripiprazole (0.1 mg - 0.4 mg). 2) Possibility of pharmaceuticals for self-injurious behavior: relatively high doses of psychostimulants induce neurotoxicity on the dopaminergic system and self-injurious behavior (SIB) in rodents. However the underlying neuronal mechanisms of SIB remain unclear. Here, we found that dopamine receptor antagonist, NMDA receptor antagonist, NOS inhibitors free radical scavengers significantly attenuated methamphetamine-induced SIB, indicating that activation of dopamine as well as NMDA receptors followed by formation of oxidative stress, especially mediated by activation NOS, is associated with methamphetamine-induced SIB. On the other hand, an increase in poly drug abuse is a major problem worldwide. Co-administered methamphetamine and morphine induced lethality by more than 80% in mice, accompanied by increase in poly (ADP-ribose) polymerase (PARP)-immunoreactive cells in the heart, kidney and liver. The lethal effect and the increase in the incidence of rupture or PARP-immunoreactive cells induced by the co-administration of methamphetamine and morphine was significantly attenuated by pretreatment with phospholipase A2 inhibitor or a radical scavenger, or by cooling from 30 to 90 min after drug administration. These results suggest that free radicals play an important role in the increased lethality induced by the co-administration of methamphetamine plus morphine. These results indicate that radical scavengers and cooling are beneficial for preventing death that is induced by the co-administration of methamphetamine and morphine. These findings may help us better understanding for masochistic behavior, especially clinical phenomenon on SIB as well as polydrug abuse induced acute toxicity.

Biography :

Toshiko Sawaguchi, M.D., Ph.D., L.B.A Research Managing Director, National Institute of Public Health, Ministry of Health Labour & Welfare, Saitama, Japan since April 2017(Life Health Promotion, Maternal & Child Health)Visiting Professor, Showa University School of Medicine, Tokyo, Japan Forensic and Paediatric Forensic Pathology and Clinical Forensic Medicine for more than 25 years,child health and paediatrics for 10years.