Journal of Antivirals & Antiretrovirals
Open Access

A furan fatty acid 7,10-epoxy octadeca 7,9-dienoic acid: A synergistic antibacterial agent against multidrug-resistant Staphylococcus aureus

Joint Event on 4^th International Conference on Antimicrobials, Multiple Drug Resistance & Antibiotics Resistance & 4^thInternational Conference on Antibiotics R&D, B2B

April 20-21, 2018 Las Vegas, USA

Ji-Sun Moon, Yeon-Jung Lee, Chakradhar Dasagrandhi, Ching T Hou and Hak-Ryul Kim

Kyungpook National University, Korea
USDA, USA

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Structural modification of natural lipids by biocatalysis can change their properties or even create novel functionalities. Hydroxy fatty acid, one of oxylipins, can be produced from the microbial bioconversion of natural vegetable oils. Recently 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) was produced with high yield from olive oil containing oleic acid by bacterial strain Pseudomonas aeruginosa PR3, and further study confirmed that DOD contained strong antimicrobial activities against broad range of microorganisms. In this study, we tried to modify DOD molecules by physical reaction to create new functionality or to enhance the antimicrobial activity of DOD. After the harsh heat-treatment, a novel furan fatty acid (EODA) was produced from DOD. We confirmed that EODA presented strong antibacterial activity against multidrug-resistant Staphylococcus aureus and also EODA showed a recuperative effect of the beta-lactam antibiotics activity against methicillinresistant Staphylococcus aureus

Biography :

Ji-Sun Moon is a graduate student in School of Food Science and Biotechnology, Kyungpook National University in Daegu Korea..
Email:hakrkim@knu.ac.kr