Journal of Leukemia
Open Access

Lymphocytic Myeloma Journals

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are both lymph proliferative diseases affecting B-cell lymphocytes. The coexistence of CLL and MM is rare. Recent PUBMED search yielded four reported manuscripts in English literature describing 22 patients [1-4]. CLL is the most common leukemia in the United States of America. It typically presents in older age, usually in the seventh decade of life. There is a male predilection. The clinical course is commonly indolent. At times, patients can present with an advance stage, warranting immediate therapy. Approximately 10-20% of CLL patients can experience transformation to diffuse large B-cell lymphoma or its immunoblastic variant [2]. This transformation is called Richter’s syndrome. MM is a plasma cell dyscrasia which affects the mature B-cell lymphocytes. Risk factors include advancing age (median age of 60-65 at presentation), male gender, and African-American decent. According to The WHO 2008 classification of hematological diseases identifies the following criteria to be met for multiple myeloma