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The primary objective of drug metabolism is to facilitate a drug’s excretion by increasing its hydrophilicity. The involved chemical modifications incidentally decrease or increase a drug’s pharmacological activity and/or half-life, the most extreme example being the metabolic activation of inactive prodrugs into active drugs, e.g. of codeine into morphine by CYP2D6. The principal organs of drug metabolism are the liver and the small intestine. Drugs completely inactivated during the first-pass through these organs must be given parenterally, similarly to poorly absorbed drugs.
Research Article: Journal of Drug Metabolism & Toxicology
Short Communication: Journal of Drug Metabolism & Toxicology
Editorial: Journal of Drug Metabolism & Toxicology
Research Article: Journal of Drug Metabolism & Toxicology
Editorial: Journal of Drug Metabolism & Toxicology
Research Article: Journal of Drug Metabolism & Toxicology
Short Article: Journal of Drug Metabolism & Toxicology
Research Article: Journal of Drug Metabolism & Toxicology
Posters & Accepted Abstracts: Journal of Developing Drugs
Keynote: Journal of Developing Drugs
Accepted Abstracts: Biochemistry & Pharmacology: Open Access
Scientific Tracks Abstracts: Biochemistry & Pharmacology: Open Access
Scientific Tracks Abstracts: Biochemistry & Pharmacology: Open Access